Adult osteomyelitis: Debridement versus debridement plus Osteoset T® pellets

Published online: Apr 30 2007

Wang Chang, Marco Colangeli, Simone Colangeli, Claudia Di Bella, Enrico Gozzi, Davide Donati

Musculoskeletal Oncology Department of the Rizzoli Orthopaedic Institute, Bologna, Italy


This long-term retrospective study investigated the value of debridement versus debridement and Osteoset T® antibiotic-loaded calcium sulphate pellets in the treatment of adult chronic osteomyelitis.

Sixty-five patients were included in the study. The mean follow-up was 75 months (range : 36 to 334). Forty cases were treated by debridement, and 25 by debridement and Osteoset T®. The healing rates were 60% and 80%, respectively ; however, the difference was not significant.

In a subgroup of 39 patients with medullary osteomyelitis and a normal immune system (IA according to the Cierny-Mader classification of adult osteomyelitis), 22 patients were treated with debridement, 17 with debridement and Osteoset T®. The healing rates were 59% and 94%, respectively (p < 0.05).

Twenty-eight patients with Staphylococcus aureus osteomyelitis were also studied apart ; 13 were treated with debridement and 15 with debridement and Osteoset T®. The healing rates were 46% and 80%, respectively. The difference was not significant.

The results obtained with debridement were less good than with debridement plus Osteoset T®, but the difference was not significant, except in a single subgroup.
gentamycin beads. Bony ingrowth is however limited.

Osteoset T® obviates the need for removal, which is the rule after implantation of